高压氧联合盐酸法舒地尔治疗急性进展性脑梗死临床疗效观察

 目的观察高压氧联合盐酸法舒地尔治疗急性进展性脑梗死的临床疗效。方法200 例急性进展性脑梗死患者随机分为治疗玉组（P盐酸法舒地尔组）、治疗域组（P高压氧联合半量盐酸法舒地尔组）、治疗芋组（P高压氧联合足量盐酸法舒地尔组）和对照组，每组50 例。结果治疗组各组基本痊愈率、总有效率显著高于对照组（P < 0.01）。治疗组各组神经功能缺损评分较治疗前显著降低（P < 0.01）。治疗域组和治疗芋组的基本痊愈率、总有效率显著高于治疗玉组（P < 0.01）。治疗域组和治疗芋组的基本痊愈率、总有效率之间无统计学差异（P > 0.01）。结论高压氧联合盐酸法舒地尔可有效改善进展性脑梗死患者的临床预后，是治疗进展性脑梗死安全有效的方法，同时使用高压氧后可减少药物的用量而对治疗效果无显著影响。

Clinical Observation on Acute Progressive Cerebral Infarction Treated by Hyperbaric Oxygen Combined with Fasudil Hydrochloride

Objective To evaluate the clinical effects of fasudil hydrochloride on patients with acute progressive cerebral infarction. Meth-ods 200 cases of acute progressive cerebral infarction patients were randomly divided into treatment group Ⅰ （Pfasudil hydrochloride，n =50），treatment group Ⅱ（Phyperbaric oxygen combined with half dose of fasudil hydrochloride，n =50），treatment group Ⅲ（Phyperbaric oxy-gen combined with enough fasudil hydrochloride，n =50）and control group（n =50）. Results Basic recovery rate and total effective rate of each treatment group was significantly higher （P < 0.01）than control group. The neurologic impairment score of each treatment group was significantly lower （P < 0.01）than that before treatment. Among the three treatment groups，basic recovery rate and total effective rate of group Ⅱand group Ⅲwere obviously higher than group Ⅰ（P < 0.01），but no significant difference was found betwwen group Ⅱand group Ⅲ. Conclusion Fasudil hydrochloride combined with hyperbaric oxygen can effectively improve the clinical prognosis of patients with acute progressive cerebral infarction. Hyperbaric oxygen can decrease the dosage of fasudil hydrochloride without influencing its efficacy.