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国产醋氨己酸锌治疗消化性溃疡疗效观察
引用本文:冯常炜,崔广林,李振峰,赵治国,唐芙爱,段芳龄.国产醋氨己酸锌治疗消化性溃疡疗效观察[J].郑州大学学报(医学版),2001,36(3):327-328.
作者姓名:冯常炜  崔广林  李振峰  赵治国  唐芙爱  段芳龄
作者单位:河南医科大学第二附属医院消化内科
摘    要:目的 :观察醋氨己酸锌 (ZAC)治疗消化性溃疡的有效性及安全性。方法 :采用随机对照双盲双模拟方法治疗经胃镜检查证实的消化性溃疡 135例。ZAC治疗组 6 8例 ,其中十二指肠溃疡 (DU) 4 7例 ,胃溃疡 (GU) 2 1例 ;应用ZAC 0 .3g ,口服 ,3次 /d。西米替丁组 6 7例 ,其中DU 46例 ,GU 2 1例 ,应用西米替丁 0 .2g ,口服 ,3次 /d ,晚睡前服0 .4g。疗程 :DU 4周 ,GU 6周 ,结果 :溃疡愈合率ZAC组DU为 48% ,GU为 6 9% ;西米替丁组DU为 5 2 % ,GU为5 0 % ,2组比较差异无显著性 (P >0 .0 5 )。疼痛症状缓解率ZAC组DU为 70 % ,GU为 10 0 % ;西米替丁组DU为87% ,GU为 86 % (P >0 .0 5 ) ;不良反应率ZAC组为 16 % ,西米替丁组为 11% (P >0 .0 5 )。结论 :ZAC是一种有效的治疗消化性溃疡的药物。

关 键 词:醋氨己酸锌  西米替丁  胃溃疡  十二指肠溃疡
修稿时间:2000年12月20

Curative effect of zinc acexamate on peptic ulcer
FENG Changwei,CUI Guanglin,Li Zhenfeng,Zhao Zhiguo,TANG Fuai,DUAN Fangling.Curative effect of zinc acexamate on peptic ulcer[J].Journal of Zhengzhou University: Med Sci,2001,36(3):327-328.
Authors:FENG Changwei  CUI Guanglin  Li Zhenfeng  Zhao Zhiguo  TANG Fuai  DUAN Fangling
Abstract:Aim: To evaluate the clinical efficacy and safety of zinc acexamate(ZAC) in treating peptic ulcer.Methods:A total of 135 patients with peptic ulcer proven by endoscopy entered arandomized double blind,double dummy study.Sixty eight patients received ZAC 0.3 g,3 times per day,including 47 with duodenal ulcer(DU) and 21 with gastric ulcer(GU);67 patients among whom 46 with DU and 21 with GU received cimitidine 0.2 g,3 times per day,and 0.4 g before sleeping in the evening.The course was DU 4 weeks,and GU 6 weeks.Results:There was no difference in DU and GU healing rates of ZAC group and cimitidine group(48% vs 52% and 69% vs 50%, P >0.05).The pain relief rates of ZAC group and cimitidine group were similar(DU,70% vs 87% and GU,100% vs 86%, P >0.05).The adverse reaction of ZAC group was 16%,and that of cimitidine group was 11%( P >0.05).Conclusion:ZAC is an effective drug in the treatment of peptic ulcer.
Keywords:zinc acexamate  cimitidine  gastric ulcer  duodenal ulcer
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