| 复方车前凝胶贴膏的制备及初步评价 |
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| 引用本文： | 夏珍珍,陈柽,李冰韶,王永洁,谢远平,林红梅,吴清. 复方车前凝胶贴膏的制备及初步评价[J]. 天津中医药大学学报, 2018, 37(2): 149-154 |
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| 作者姓名： | 夏珍珍 陈柽 李冰韶 王永洁 谢远平 林红梅 吴清 |
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| 作者单位： | 北京中医药大学中药学院; |
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| 基金项目： | 国家自然科学基金资助项目（81473365）。 |
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| 摘 要： | [目的]研究旨在将复方车前水浸膏制备为易于使用的复方车前凝胶贴膏。[方法]采用Plackett-Burman设计联合Box-Behnken响应面优化法,以初黏力、持黏力、180°剥离强度为评价指标,优选最佳制备处方。采用改良Franz扩散池法,以京尼平苷酸为指标,研究其体外释放行为。以小鼠H22肝癌腹水模型对其药效进行评价。[结果]优化得到复方车前凝胶贴膏的基质配方为NP700,PVPK90,甘油,甘羟铝,酒石酸,蒸馏水(8∶5.38∶32.5∶0.5∶0.5∶44.62)。凝胶膏中京尼平苷酸24 h体外释放(81.23±1.52)%。给药7 d后,与模型组相比,贴膏组与浸膏组小鼠腹水量显著减少(P0.01),腹水中VEGF的量显著下降(P0.05),免疫功能破坏得到显著改善(P0.05),且贴膏组与浸膏组差异无统计学意义。[结论]复方车前凝胶膏的处方合理,制备的凝胶膏黏性良好,指标成分京尼平苷酸体外释放率符合一级动力学方程,复方车前凝胶贴膏能有效减少小鼠腹水量,效果显著。
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| 关 键 词： | Plackett-Burman Box-Behnken 凝胶贴膏 体外释放 H22肝癌腹水模型 |
| 收稿时间： | 2017-11-20 |
Preparation and preliminary evaluation of compound plantaginis semen gel paste |
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| XIA Zhenzhen,CHEN Cheng,LI Bingshao,WANG Yongjie,LIN Hongmei and WU Qing. Preparation and preliminary evaluation of compound plantaginis semen gel paste[J]. Journal of Tianjin University of Traditonal Chinese Medicine, 2018, 37(2): 149-154 |
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| Authors: | XIA Zhenzhen CHEN Cheng LI Bingshao WANG Yongjie LIN Hongmei WU Qing |
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| Affiliation: | School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China,School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China,School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China,School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China,School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China,School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China and School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China |
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| Abstract: | |
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| Keywords: | Plackett-Burman Box-Behnken Gel Paste in vitro release H22 hepatoma ascites model |
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