中西医结合治疗儿童上气道咳嗽综合征疗效的Meta分析

[目的]探讨中西医结合治疗儿童上气道咳嗽综合征的疗效。[方法]根据系统评价的要求,检索中国期刊全文数据库、万方数据库、中国生物医学文献数据库,对符合纳入标准的7篇文献共计582例患儿进行了Meta分析。[结果]发表偏倚分析:7篇文献以总有效率做倒置漏斗图,显示呈大致对称分布,但分布范围主要集中于中上部;以显效率做倒置漏斗图,显示不对称分布,均提示存在一定的方法学质量低下和发表偏倚。异质性检验:观察组与对照组具有临床及统计学上的同质性,用固定效应模型进行分析,分析结果显示:中西医结合与单纯西医治疗儿童上气道咳嗽综合征的总有效率差异和显效率差异均有统计学意义。[结论]从现有的临床证据来看,中西医结合治疗儿童上气道咳嗽综合征有效,且疗效优于单纯西药治疗,中西医结合疗法可以缩短儿童上气道咳嗽综合征的治疗时间,但还需要严格设计的大样本随机、双盲、对照试验进行进一步验证和支持。

Therapeutic effect of integrated traditional Chinese and western medicine treating upper airway cough syndrome in children: a Meta analysis

[Objective] To investigate the therapeutic effect of integrated traditional Chinese and Western Medicine treating upper airway cough syndrome in children.[Methods] Retrieve comprehensively in accordance with the requirements of the system evaluation including CNKI, Wanfang database, and CBM etc. Seven literature with 582 cases were included and a meta analysis was conducted.[Results] Publication bias analysis revealed that the total effective inverted funnel plot of the 7 literature was roughly symmetrical with the distribution scope mainly concentrated in the middle and upper part; the markedly effective inverted funnel plot was asymmetrical; both of which suggested that there was a certain publication bias and low methodological quality. Heterogeneity test:the observation group and the control group had clinical and statistical homogeneity and can be analysed with fixed effect model. The result revealed that there was significant difference between the observation group and the control group in the espect of both total effect and marked effect.[Conclusion] According to the present clinical evidence, it was efficacy to treat upper airway cough syndrome in children with integrated traditional Chinese and western medicine and the effect was better than simply with western medicine. Integrated traditional Chinese and western medicine therapy may reduce treatment duration of upper airway cough syndrome in children. While it needs rigorous design and to be further identified and supported by large sample random, double blind, controlled trials.