奎硫平治疗老年期痴呆伴行为和精神障碍对照研究

目的：探讨奎硫平治疗老年期痴呆患者的行为和精神症状疗效及不良反应，并与利培酮对照。方法：对76例老年期痴呆患者随机分为奎硫平组和利培酮组，疗程8周。采用阿尔茨海默病病理行为评定表（BEHAVE-AD）及治疗中出现的症状量表（TESS）评定疗效和不良反应。结果：奎硫平与利培酮对老年期痴呆伴发的精神障碍疗效可靠。有效率奎硫平组94．7％，利培酮组94．9％，不良反应少。结论：奎硫平对老年期痴呆伴发的精神行为障碍患者安全有效，适合临床使用。

Comparative study of quetiapine in the treatment of patients with senile dementia accompanied with psychiatric symptoms

Objective： To evaluate and compare the efficacy and adverse effects in the treatment of patients with senile dementia accompanied with psychiatric symptoms between quetiapine and risperidone. Method ：76 patients with senile dementia were randomly divided into quetiapine group and risperidone group for 8 weeks. Behavioral pathology in Alzhimer＇s disease rating scale（ BEHAVE -AD） was used to access the efficacy and treatment emergent symptoms scale （TESS） was used to evaluate the adverse effects. Resnits： Both quetiapine and risperidone provided progressive improvement in patients with senile dementia accompanied with psychiatric symptoms,with response rate 94.7% for quetiapine group and 94.9% for risperidone group and less adverse effects both. Conclusion： Quetiapine was effective and safe in the treatment of patients with senile dementia and was suitable for clinical use.