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MHC-restricted presentation of a single repeat of MUC1 mucin |
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| Authors: | Orr Melody K Burnside Janet S Phillips Catherine A Philip Ramila Dombrowski Kenneth E Wright Stephen E |
| Affiliation: | a Departments of Internal Medicine and Women's Health and Research Institute, Texas Tech University Health Sciences Center, Amarillo, Texas, USAb Cell Biology and Biochemistry; Microbiology and Immunology, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USAc Veterans Affairs Medical Center, Amarillo, Texas, USAd Departments of Molecular Biology and Cancer Biology, RPR GenCell, Inc. (formerly Applied Immune Sciences, Inc., (AIS)), Santa Clara, California, USAe Department of Veterans Affairs and the Atlanta Research and Education Foundation, Decateur, Georgia, USAf Departments of Microbiology/Immunology, Emory University School of Medicine, Atlanta, Georgia, USAg Department of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, USA |
| Abstract: | Major histocompatibility complex (MHC) restriction of antigen presentation of a single mucin1 (MUC1) variable number of tandem repeats peptide (VNTR1) was examined by generating cytotoxic T lymphocytes (CTL) derived from peripheral blood mononuclear cells (PBMC) stimulated with a single repeat MUC1 peptide presented by allogeneic (MHC-independent) or autologous (MHC-dependent) Epstein-Barr Virus (EBV) immortalized B lymphocytes. The ability to generate greater CTL activity against MUC1-expressing tumor cells by stimulation with autologous versus allogeneic EBV-B supports the hypothesis that presentation of a single repeat of MUC1 peptide is MHC-restricted (MHC-dependent). |
| Keywords: | MUC1 MHC restriction |
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