| 三七总皂苷对大鼠脑缺血再灌注损伤保护作用及机制的实验研究 |
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| 引用本文： | 寇幸福,王志方.三七总皂苷对大鼠脑缺血再灌注损伤保护作用及机制的实验研究[J].河南中医学院学报,2008,23(6). |
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| 作者姓名： | 寇幸福 王志方 |
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| 作者单位： | [1]西华县人民医院,河南西华466600 [2]郑州市第九人民医院,河南郑州450053 |
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| 摘 要： | 目的:探讨三七总皂苷注射液对局灶性脑缺血再灌注损伤的保护作用及机制.方法:40只Wistar大鼠被随机分为4组:假手术组、缺血再灌注损伤模型组、尼莫地平对照(Nim)组、三七总皂苷注射液处理组(PNS).建立大鼠大脑中动脉缺血再灌注损伤模型,对脑水肿和脑梗死进行测量,并采用硫代巴比妥酸盐法测定MDA含量、邻苯三酚自氧化法测定SOD活性.结果:PNS组与模型组比较,脑组织含水量减少(P<0.01),脑梗死面积显著减小(P<0.05);SOD活力显著升高(P<0.05),MDA含量显著降低(P<0.05).结论:MDA是反映组织损伤程度的物质、SOD是体内重要的内源性保护物质,三七总皂苷注射液可降低缺血脑组织MDA的含量、增加SOD活性而发挥对脑的保护作用.
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| 关 键 词： | 三七总皂苷 脑缺血再灌注损伤 |
The Empirical Study of Panax Pseudo-Ginseng Total Saponin to Cerebral Ischemical Reperfusion Injury Protection |
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| Kou Xingfu,Wang Zhifang Xihua County People's Hospital,Xihua,Henan,China,NO. People's Hospital of Zhengzhou.The Empirical Study of Panax Pseudo-Ginseng Total Saponin to Cerebral Ischemical Reperfusion Injury Protection[J].Journal of Henan University of Chinese Medicine,2008,23(6). |
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| Authors: | Kou Xingfu Wang Zhifang Xihua County People's Hospital Xihua Henan China NO People's Hospital of Zhengzhou |
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| Institution: | Kou Xingfu1,Wang Zhifang2 Xihua County People's Hospital,Xihua,Henan,China,466600NO.9 People's Hospital of Zhengzhou,450053 |
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| Abstract: | Objective:To investigate the protective effects and its mechanism of Panax Notoginseng Saponins,(PNS)on cerebral ischemia reperfusion injury(CIRI) in rats. Method: 40 Wistar rats were divided in to 4 groups randomly: sham operation, ischemia reperfusion injury (IR), nimodipine, and PNS injection group. The model of middle cerebral artery occlusion (MCAO) ischemia reperfusion injury was produced, After cerebral ischemia lasting for 2 h, then reperfusion for 24 h. The activities of superoxide dismutase (SOD),... |
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| Keywords: | SOD MDA |
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