伊曲康唑注射液治疗恶性血液病侵袭性真菌感染的临床研究

目的研究伊曲康唑注射液治疗血液恶性病患者合并侵润性真菌感染的疗效。方法对30例按标准诊断患者应用伊曲康唑注射液,剂量200~400mg/d第1天,以后200mg/d用药14天。结果临床总有效率为66.7%,确诊病例、临床诊断病例与拟诊病例有效率分别为71.3%、86.3%、25.0%。确诊病例、临床诊断病例与拟诊病例有效率之间相比,有统计学差异(P<0.05);粒细胞减少,应用广谱抗生素及糖皮质激素是发病的主要危险因素;伊曲康唑注射液起效时间3天~7天,中位时间4天。结论伊曲康唑注射液对恶性血液病合并侵袭性真菌感染疗效显著,对存在危险因素的患者早期诊断,积极治疗,可取得良好效果。

Efficacy of intravenous itraconazole on invasive fungal infections in patients with hematological malignancies

Objective: To investigate the efficacy of intravenous administration of itraconazole on invasive fungal infections(IFI) in patients with hematological malignancies. Methods: Thirty patients with hematological malignancies who were diagnozed according to the criteria of invasive fungal infections underwent intravenous injection of itraconazole 200mg bid for first day and then qd for at least 2 weeks. Results: The total effective rate was 66.7%. The effective rates of the patients with confirmed diagnosis, clinical diagnosis, and with recommended diagnosis respectively were 71.3%, 86.3% and 25.0%,there was a significant difference between the patients with confirmed diagnosis, clinical diagnosis and patients with recommended diagnosis(P<0.01).The main danger factors of IFI were neutrocytopenia, administration of broad-spectrum antibiotic and glucocorticoid for a long-time. Conclusion: Itraconazole injection is effective and safe in treatment of invasive fungal infections in patients with hematological malignancy