Membrane properties of deep dorsal horn neurons from neonatal rat spinal cord in vitro |
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Authors: | Shawn Hochman Sandra M Garraway Susan Pockett |
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Affiliation: | aDepartment of Physiology, Room 420, Basic Medical Sciences Building, University of Manitoba, 770 Bannatyne Ave., Winnipeg, MB R3E 0W3, Canada;bDepartment of Physiology, University of Auckland, Private Bag 92019, Auckland, New Zealand |
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Abstract: | Whole-cell patch-clamp recordings were undertaken to characterize and compare the membrane properties of deep dorsal horn neurons in transverse slices of rat lumbar spinal cord in two age groups, postnatal days (P) 3–6 and 9–16. In both age groups, significant correlations were observed between membrane time constant and cell resistance and between action potential height and its duration at half-maximal amplitude. Cell resistance and action potential half-width values were lower in the P9–16 age group. Neurons were divided into four categories based on their firing properties in response to intracellular current injection: single spike, phasic firing, repetitive firing, and delayed firing. The distribution of neurons within these categories was similar in both age groups which suggests that the firing properties of deep dorsal horn neurons are functionally differentiated at an early postnatal age. |
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Keywords: | Spinal cord Development Slice |
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