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Effects of chronic ibogaine treatment on cerebellar Purkinje cells in the rat |
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| Authors: | Scott Helsley Cynthia A Dlugos Roberta J Pentney R.A Rabin J.C Winter |
| Affiliation: | aDepartment of Pharmacology and Toxicology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 102 Farber Hall, Buffalo, NY 14214-3000, USA;bDepartment of Anatomy and Cell Biology, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, 102 Farber Hall, Buffalo, NY 14214-3000, USA |
| Abstract: | The present investigation assessed the chronic toxicity of ibogaine on cerebellar Purkinje cells in male Fischer 344 rats. A behaviorally active dose of ibogaine (10 mg/kg, i.p.) was administered to a group of six subjects every other day for 60 days while the control group received an equivalent volume of saline (1 ml/kg). Estimates of Purkinje cell number were determined using the optical dissector/fractionator technique. No significant differences in Purkinje cell number were observed between the ibogaine (243764[±32766]) and control groups (230813[±16670]). |
| Keywords: | Ibogaine Purkinje cell Optical dissector Chronic toxicity |
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