山茱萸环烯醚萜总苷对2型糖尿病心脏病变大鼠胰岛素抵抗及血脂含量的影响

目的:观察山茱萸环烯醚萜总苷(ICO)对2型糖尿病心脏病变大鼠胰岛素抵抗及血脂含量的影响。方法:大鼠以高脂饲养结合STZ腹腔注射造模,2周后灌胃给予ICO(0.1,0.2g/kg)或氨基胍(AG,0.1g/kg)治疗,连续16周。检测体重、空腹血糖、血清Ins、Ins-Ab、CHOL、TG、HDL-C及LDL-C含量;分离心脏进行形态学观察。结果:模型组大鼠体重、血糖、Ins-Ab、IR、CHOL、TG、LDL-C明显升高,Ins水平显著降低;光镜检查显示心肌肥大伴程度不等的间质水肿和组织细胞增生,心内膜或心包膜有轻度炎症及纤维化。ICO及AG组大鼠体重、血糖、Ins-Ab、IR、CHOL、TG、LDL-C均明显降低,心肌肥大程度减轻。结论:ICO对2型糖尿病心脏病变有一定的保护作用。

Protecting effect of total iridoid glycoside in Fructus Corni Officinalis on IR and blood lipid level of rats with type 2 diabetic cardiopathy

Objective:To investigate the protecting effect of total iridoid glycoside in Fructus Corni Officinalis(ICO) on IR and blood lipid level of rats with type 2 diabetic cardiopathy.Method:Models were made with high-fat diet and STZ injection.Two weeks later,ICO(0.1,0.2 g/kg) and AG(0.1 g/kg) were used in the treatment for 16 weeks.Result:In the model group,weight,blood sugar,serum Ins-Ab,IR,CHOL,TG and LDL-C of the rats increased,the levels of serum Ins decreased markedly(P < 0.05,P < 0.01),overgrowth of the heart muscle occurred as revealed by optical microscope,varying degrees of matrix edema and tissue cell hyperplasia appeared,and there were mild inflammation and fibrosis in the endocardium and pericardium.After the application of ICO and AG,the symptoms were relieved.Conclusion:ICO has protecting effect on type 2 diabetic cardiopathy.