Antiprotozoal sesquiterpene pyridine alkaloids from Maytenus ilicifolia |
| |
Authors: | Santos Vânia A F F M Regasini Luis O Nogueira Cláudio R Passerini Gabriela D Martinez Isabel Bolzani Vanderlan S Graminha Márcia A S Cicarelli Regina M B Furlan Maysa |
| |
Affiliation: | Departamento de Química Organica, Instituto de Química, Universidade Estadual Paulista (UNESP), Araraquara, SP 14800-900, Brazil. vaniaapf@gmail.com |
| |
Abstract: | As part of a bioprospecting program aimed at the discovery of antiprotozoal agents from the Brazilian flora, two new sesquiterpene pyridine alkaloids, ilicifoliunines A (1) and B (2), along with the known alkaloids aquifoliunine E-I (3) and mayteine (4), were isolated from the root bark of Maytenus ilicifolia. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. Alkaloid 3 displayed potent in vitro antiprotozoal activity against Leishmania chagasi and Trypanosoma cruzi, with IC(50) values of 1.4 and 41.9 μM, respectively, as well as low cytotoxicity against murine peritoneal macrophages (IC(50) of 1.8 mM). |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|