宫颈癌辐射敏感性相关基因的研究进展

放射治疗前,对宫颈癌患者进行辐射敏感性检测以预测放疗效果的研究在肿瘤治疗中有很好的应用前景。根据细胞基因表达水平预测辐射敏感性及基因治疗逆转宫颈癌放射抵抗成为研究热点。影响宫颈癌辐射敏感性的基因主要有细胞增殖、凋亡基因和肿瘤细胞乏氧相关基因等,而基因芯片法分析多个辐射敏感相关基因,对于预测宫颈癌的辐射敏感性和治疗可能更有意义。

The development of genes associated with radiosensitivity of cervical cancer

It has a good application prospect to predict effeets of radiotherapy by examining radiosensitivity of patients with cervical cancers before their radiotherapy. Prediction of tumor cell radiosensitivity according to their level of gene expression and gene therapy to reverse radio-resistance prior to radiation on cervical cancers are heated researches on tumor therapy. The expression of some proliferation-related genes,apoptosis-related genes and hypoxia-related genes can inerease the radiosensitivity of cervical cancer. Microarray technology may have more direct applications to the study of biological pathway contributing to radiation resistance and may lead to development of alternative treatment modalities.