Cortical projections of monoamine oxidase-containing neurons from the posterior hypothalamus in the rat |
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| Authors: | H Tago H Kimura K Kitahama K Sakai M Jouvet T Maeda |
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| Affiliation: | 1. Division of Child Psychiatry, Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205 U.S.A.;2. Division of Child Psychiatry, Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205 U.S.A.;3. Division of Child Psychiatry, Department of Pharmacology, Johns Hopkins University School of Medicine, Baltimore, MD 21205 U.S.A.;4. Division of Child Psychiatry, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205 U.S.A. |
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| Abstract: | The dipeptide, L-phenylalanyl-L-glutamate (PG), augments the specific binding of the excitatory amino acid receptor antagonist, [3H]2-amino-7-phosphonoheptanoic acid (APH), to rat forebrain membranes by 5-fold at 100 microM with an EC50 of 4.9 microM. The increase in the specific binding of [3H]AHP induced by PG results exclusively from an increase in Bmax. In contrast, PG inhibits the specific binding of [3H]kainic acid to forebrain membranes with a Ki of 6.8 microM. Of several related peptides examined, active ones affected the two receptor sites in a reciprocal fashion. The results suggest an allosteric interaction between [3H]APH and kainate receptors modulated by glutamate-containing peptides. |
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| Keywords: | amino-phosphono-heptanoic acid kainic acid peptides excitatory receptors |
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