| 替比夫定治疗慢性乙型肝炎的临床研究 |
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| 引用本文： | 汤东澄,谢冬梅,徐娟娟,何俊毅,姚立红,杨壮智,李永丰. 替比夫定治疗慢性乙型肝炎的临床研究[J]. 浙江中医药大学学报, 2009, 33(2): 214-215 |
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| 作者姓名： | 汤东澄 谢冬梅 徐娟娟 何俊毅 姚立红 杨壮智 李永丰 |
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| 作者单位： | 浙江省永嘉县中医医院,永嘉,325102 |
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| 摘 要： | [目的]探讨替比夫定治疗慢性乙型肝炎的疗效。[方法]将164例慢性乙型肝炎患者分为治疗组85例，对照组79例，分别应用替比夫定和拉米夫定抗病毒治疗48周以观察其疗效。[结果]治疗组和对照组ALT复常率，HBeAg阳性分别为87．50％和71．15％；HBV DNA下降值HBeAg阳性为-5．3和-4．2log10 copies／ml，阴性为-6．6和-5．5log 10copies／ml；HBeAg转阴率分别为28．57％和23．08％；HBeAg血清转换率为23．21％和15．38％；耐药率HBeAg阳性为3．57％和11．53％，阴性为3．45％和14．81％；差异有显著性（P〈0．05）。[结论]替比夫定具有抗乙型肝炎病毒特异性，与拉米夫定比较，其抑制病毒能力强，病毒耐药发生率低，HBeAg血清转换率高，安全性好。
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| 关 键 词： | 乙型肝炎 病毒 替比夫定 拉米夫定 |
Clinical Study on Telbivudine Treating Chronic Hepatitis B |
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| Tang Dongdeng,Xie Dongmei,Xu Juanjuan,et al Yongjia County Hospital of Zhejiang Province. Clinical Study on Telbivudine Treating Chronic Hepatitis B[J]. Journal of Zhejiang University of Traditional Chinese Medicine, 2009, 33(2): 214-215 |
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| Authors: | Tang Dongdeng Xie Dongmei Xu Juanjuan et al Yongjia County Hospital of Zhejiang Province |
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| Abstract: | [Objective] To discuss the efficacy of Telbivudine treating chronic hepatitis B.[Method] Randomly divide 164 cases into treatment group 85 and control one 79,respectively taking Telbivudine and Ramivudine for anti virus for 48 w,then observe their efficacy.[Result] The ALT normalization and HbeAg positive rates were separately 87.50% and 71.15% for both groups; HBV DNA reduction rates and HbeAg postive-5.3 and-4.2log10 copies/ml,negative-6.6 and-5.5 log10 copies/ml;HbeAg negative rates respectively 28.57% a... |
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| Keywords: | hepatitis B virus Telbivudine Ramivudine |
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