Recent advances in,and challenges of,anti-angiogenesis agents for tumor chemotherapy based on vascular normalization |
| |
Affiliation: | 1. School of Pharmacy, Health Science Center, Xi’an Jiaotong University, Xi’an 710061, China;2. Department of Pharmacy, Shenzhen Baoan Authentic TCM Therapy Hospital, Shenzhen 518101, China |
| |
Abstract: | A major problem associated with cancer treatment is resistance-prone chemotherapeutic drugs. An increasing number of studies have documented that the occurrence of resistance tends to be associated with abnormal blood vessels. In 2001, Jain proposed the vascular normalization theory, which was recently applied to the drug-resistant treatment of tumors in the clinic. Through the intervention of angiogenesis inhibitors, remodeling the structure and function of abnormal vessels can maximize the efficacy of chemotherapeutic drugs. In this review, we systematically describe the occurrence and progress of tumor angiogenesis, as well as the pathological characteristics of tumor blood vessels. Moreover, druggable targets for vascular normalization and the development of related inhibitors are also outlined. |
| |
Keywords: | Drug resistance Tumor angiogenesis Vascular normalization Anti-angiogenesis inhibitors Multiplex inhibitors |
本文献已被 ScienceDirect 等数据库收录! |
|