Selection of the mobilization regimen in lymphoma patients: A retrospective cohort study |
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| Institution: | 1. Inonu University, Department of Hematology, Malatya, Turkey;2. Inonu University, Faculty of Pharmacy, Department of Clinical Pharmacy, Malatya, Turkey;1. Division of Pediatric Intensive Care, Department of Pediatrics, Ankara City Hospital, Ankara, Turkey;2. Division of Pediatric Intensive Care, Department of Pediatrics, Medical School, Ankara University, Ankara, Turkey;3. Division of Pediatric Oncology, Department of Pediatric, Medical School, Ankara University, Ankara, Turkey;4. Division of Pediatric Intensive Care, Department of Pediatrics, Dr. Sami Ulus Maternity and Children''s Training and Research Hospital, Ankara, Turkey;5. Department of Pediatrics, Ankara City Hospital, Ankara, Turkey;1. University of Health Sciences, Ankara Oncology Training and Research Hospital, Department of Hematology & Apheresis Unit, Ankara, Turkey;2. Inonu University, Department of Hematology, Malatya, Turkey;3. University of Health Sciences, Antalya Training and Research Hospital, Department of Hematology, Antalya, Turkey;4. Istanbul University, Istanbul Medical Faculty, Department of Internal Medicine, Division of Hematology, Istanbul, Turkey;5. Near East University, School of Medicine, Department of Internal Medicine, Division of Hematology, Nicosia, Cyprus;6. Ankara Yildirim Beyazit University, School of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, Turkey;1. Student Research Committee, Faculty of Allied Medicine, Kerman University of Medical Sciences, Kerman, Iran;2. Cell Therapy and Regenerative Medicine Comprehensive Center, Kerman University of Medical Sciences, Kerman, Iran;3. Department of Hematology and Laboratory Sciences, Faculty of Allied Medical Sciences, Kerman University of Medical Sciences, Kerman, Iran;4. Research Center for Hydatid Disease in Iran, Kerman University of Medical Sciences, Kerman, Iran;5. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran;6. Department of Traditional Medicine, Faculty of Traditional Medicine, Kerman University of Medical Sciences, Kerman, Iran;7. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran;1. University of Health Sciences, Kayseri City Training and Research Hospital, Department of Internal Medicine, Medical Intensive Care Unit, Kayseri, Turkey;2. University of Health Sciences, Kayseri City Training and Research Hospital, Department of Hematology & Apheresis Unit, Kayseri, Turkey;3. Inonu University, Department of Hematology, Malatya, Turkey;4. University of Health Sciences, Gazi Yasargil Training and Research Hospital, Department of Hematology, Diyarbakir, Turkey;5. University of Health Sciences, Ankara Oncology Training and Research Hospital, Department of Hematology & Apheresis Unit, Ankara, Turkey;6. Yuzuncu Yil University, Department of Hematology, Van, Turkey;7. Ondokuz Mayis University, Department of Hematology, Samsun, Turkey;8. Near East University, School of Medicine, Department of Internal Medicine, Division of Hematology, Nicosia, Cyprus;9. Medical Park Antalya Hospital, Department of Hematology, Antalya, Turkey;10. Ankara Yildirim Beyazit University, School of Medicine, Department of Internal Medicine, Division of Hematology, Ankara, Turkey;1. Inonu University, Faculty of Medicine, Department of Hematology, Malatya, Turkey;2. Inonu University, Faculty of Medicine, Department of Gastroenterology, Malatya, Turkey;3. Inonu University, Faculty of Medicine, Department of Biostatistics and Medical Informatics, Malatya, Turkey;4. Inonu University, Faculty of Medicine, Department of Physiology, Malatya, Turkey |
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| Abstract: | Background and objectivesConsolidation with autologous stem cell transplantation (ASCT) is recommended for patients with recurrent or refractory lymphoma after salvage chemotherapy. Stem cells which will be used in ASCT are provided by mobilization using granulocyte colony stimulation factor (G-CSF) or chemotherapy plus G-CSF. The aim of this study was to compare the effect of various mobilization regimens on the clinical parameters of lymphoma patients.Materials and methodsMobilization interventions of lymphoma patients were analysed retrospectively. The patients were divided into 3 groups according to the mobilization method implemented to collect stem cells before ASCT, (Group 1: Salvage chemotherapy plus G-CSF, Group 2: Cyclophosphamide plus G-CSF, Group 3: G-CSF alone).ResultsAnalysis of CD34+ cell counts of the 3 groups revealed a significant difference (p < 0.001). Although the number of CD34+ cells collected were different, the neutrophil and platelet engraftment of the 3 groups were similar (p > 0.05). Furthermore, the results were similar in the separate analysis of NHL and HL patients. While the mobilization success rate in group 1 was 97.8 %, it was 90.2 % in group 3. This difference showed a certain trend towards statistical significance (p = 0.074). Patients who received DHAP plus G-CSF had a higher CD34+ count, while neutrophil engraftment was shorter than with ESHAP plus G-CSF (p < 0.05).ConclusionAlthough the success rate of mobilization and number of CD34+ cell collected were higher in the salvage chemotherapy plus G-CSF than G-CSF alone, G-CSF alone group provided similar neutrophil and thrombocyte engraftment in most lymphoma patients. |
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| Keywords: | DHAP Cyclophosphamide Lymphoma ESHAP G-CSF Mobilization |
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