Erythrocyte transfusion restored heart rate variability in children with thalassemia major |
| |
| Affiliation: | 1. Department of Physiology, Istanbul Health Sciences University, Faculty of Medicine, Istanbul, Turkey;2. Department of Physiology, Inonu University, Faculty of Medicine, Malatya, Turkey;3. Department of Pediatric Hematology and Oncology, Inonu University, Faculty of Medicine, Malatya, Turkey;1. Department of Immunology and Transfusion Medicine, Oslo University Hospital, Ullevaal, Oslo, Norway;2. Department of Life Sciences and Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway;3. Department of Pediatric Hematology and Oncology, Oslo University Hospital, Oslo, Norway;1. Department of Blood Transfusion, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China;2. Department of Blood Transfusion, QianJiang Central Hospital, Chongqing, China;3. Department of Dermatology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China;1. Cardiovascular Institute Dedinje, Milana Tepića 1, 11000, Belgrade, Serbia;2. Gulf Coasts Biologics Inc, 4331 Veronica S Shoemaker Blvd, Fort Myers, FL, 33916, United States;3. Clinical Centre of Serbia, Pasterova2, 11000, Belgrade, Serbia;4. St Catherine’s Hospital, Michelangelolaan 2, 5623 EJ, Eindhoven, the Netherlands;5. Emergency Medical Centre of Montenegro, Vaka Đurovića bb, 81110, Podgorica, Montenegro |
| |
| Abstract: | Thalassemia major (TM) is a severe transfusion-dependent anemia. Regular erytrocyte transfusion is required for the treatment of thalassemia patients. However, repeated transfusion may result in impairements in heart function. In this study, we aimed to investigate short-term effects of erythrocyte transfusion on autonomic control of heart in children with thalassemia major. For that purpose heart rate variability (HRV), which is a non-invasive method used to evaluate the effects of the autonomic nervous system on the heart rhythym, was measured before and after erythrocyte transfusion and compared to the healthy controls. Children diagnosed with TM (n = 17) and sex and age matched healthy children (HC, n = 30) were included in the study. HRV values of TM patients were measured 5 min before erythrocyte transfusion (BET, n = 17) and 5 min after erythrocyte transfusion (AET, n = 17). Parameters of time-domain and frequency-domain of HRV were evaluated in all participants. Heart rate (HR) was higher in the BET than AET (P = 0.002) but there was no difference between AET and HC groups (P > 0.05). HRV parameters were lower in BET than AET (P < 0.05) but there were no statistical difference between AET and HC (P> 0.05). The data suggest that, in thalassemia major patients, erythrocyte transfusion restores HR and HRV parameters to the levels observed in healthy controls and, thus, in short-terms, appears to be beneficial for the autonomic control of the heart. |
| |
| Keywords: | Thalassemia major Children Autonomic nervous system activity Heart rate variability Erythrocyte transfusion |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
