A distributed network supports spatiotemporal cerebral dynamics of visual naming |
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| Affiliation: | 1. Comprehensive Epilepsy Center, Division of Neurology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA;2. Department of Electrical Engineering and Computer Science, University of Cincinnati, Cincinnati, Ohio, USA;3. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA;4. Division of Pediatric Neuro-radiology, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA;5. Division of Pediatric Neurosurgery, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio, USA |
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| Abstract: | ObjectiveCerebral spatiotemporal dynamics of visual naming were investigated in epilepsy patients undergoing stereo-electroencephalography (SEEG) monitoring.MethodsBrain networks were defined by Parcel-Activation-Resection-Symptom matching (PARS) approach by matching high-gamma (50–150 Hz) modulations (HGM) in neuroanatomic parcels during visual naming, with neuropsychological outcomes after resection/ablation of those parcels. Brain parcels with >50% electrode contacts simultaneously showing significant HGM were aligned, to delineate spatiotemporal course of naming-related HGM.ResultsIn 41 epilepsy patients, neuroanatomic parcels showed sequential yet temporally overlapping HGM course during visual naming. From bilateral occipital lobes, HGM became increasingly left lateralized, coursing through limbic system. Bilateral superior temporal HGM was noted around response time, and right frontal HGM thereafter. Correlations between resected/ablated parcels, and post-surgical neuropsychological outcomes showed specific regional groupings.ConclusionsConvergence of data from spatiotemporal course of HGM during visual naming, and functional role of specific parcels inferred from neuropsychological deficits after resection/ablation of those parcels, support a model with six cognitive subcomponents of visual naming having overlapping temporal profiles.SignificanceCerebral substrates supporting visual naming are bilaterally distributed with relative hemispheric contribution dependent on cognitive demands at a specific time. PARS approach can be extended to study other cognitive and functional brain networks. |
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| Keywords: | Functional brain mapping Brain networks Intracranial electrodes Epilepsy surgery Cortical localization |
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