雷公藤红素治疗肥胖的研究进展

肥胖是一类常见代谢性疾病,也是引起心脑血管疾病、糖尿病和肿瘤等重大疾病的危险因素之一。目前临床用于治疗肥胖的上市药物西布曲明、奥利司他和氯卡色林等虽然疗效明确,但具有无法克服的副作用。雷公藤红素是从传统中药雷公藤根部提取的一种活性天然产物,最近的研究发现,雷公藤红素通过提升瘦素敏感性、增加体内脂肪代谢、抑制脂肪细胞生成等作用而发挥减肥效果。笔者通过综述雷公藤红素治疗肥胖的作用及相关机制,为来源于中药的天然产物治疗肥胖提供一些启示。

Research Progress of Celastrol in Obesity

Obesity is a kind of metabolic disease,which is a major risk factor of heart disease,diabetes mellitus and cancer.In recent years,the US Food and Drug Administration(FDA)has approved a stand of drugs treatment for obesity,including sibutramine,orlistat,belviq and so on,however,side effects may occur after long-term using.Celastrol is a class of pentacyclic triterpenoids extracted from the roots of Tripterygium wilfordii Hook F.It has been found that celastrol has the pharmacological activities of increasing leptin sensitivity,increasing fat metabolism,inhibiting the formation of lipocyte and inhibiting chronic inflammation in obesity animals.This overview summarizes the related mechanisms of celastrol on treatment of obesity to provide enlightenments for its further study.