fdg-pet in two cases of neurofibromatosis type 1 and atypical malignancies |
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| Authors: | P. de Blank K. Cole L. Kersun A. Green J.J. Wilkes J. Belasco R. Bagatell L.C. Bailey M.J. Fisher |
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| Affiliation: | *Department of Pediatrics, Division of Pediatric Hematology and Oncology, Rainbow Babies and Children’s Hospital, Cleveland, OH, U.S.A.;†Division of Oncology and Center for Childhood Cancer Research, The Children’s Hospital of Philadelphia, Philadelphia, PA, U.S.A.;‡Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, U.S.A. |
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| Abstract: | Patients with neurofibromatosis type 1 (nf1) are at increased risk for both benign and malignant tumours, and distinguishing the malignant potential of an individual tumour is a common clinical problem in these patients. Here, we review two cases of uncommon malignancies (Hodgkin lymphoma and mediastinal germ-cell tumour) in patients with nf1. Although 18F-fluorodeoxyglucose positron-emission tomography (fdg-pet) has been used to differentiate benign neurofibromas from malignant peripheral nerve sheath tumours, fdg-pet characteristics for more rare tumours have been poorly described in children with nf1. Here, we report the role of pet imaging in clinical decision-making in each case. In nf1, fdg-pet might be useful in the clinical management of unusual tumour presentations and might help to provide information about the malignant potential of uncommon tumours. |
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| Keywords: | Neurofibromatosis type 1 pediatric oncology Hodgkin lymphoma germ-cell tumours Klinefelter syndrome |
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