首页 | 本学科首页   官方微博 | 高级检索  
     


Inhibition of cortical somatosensory processing during and after low frequency peripheral nerve stimulation in humans
Affiliation:1. Department of Psychological Sciences, University of Liverpool, Liverpool, UK;2. Institute for Risk and Uncertainty, University of Liverpool, Liverpool, UK
Abstract:ObjectiveTranscutaneous low-frequency stimulation (LFS) elicits long-term depression-like effects on human pain perception. However, the neural mechanisms underlying LFS are poorly understood. We investigated cortical activation changes occurring during LFS and if changes were associated with reduced nociceptive processing and increased amplitude of spontaneous cortical oscillations post-treatment.MethodsLFS was applied to the radial nerve of 25 healthy volunteers over two sessions using active (1 Hz) or sham (0.02 Hz) frequencies. Changes in resting electroencephalography (EEG) and laser-evoked potentials (LEPs) were investigated before and after LFS. Somatosensory-evoked potentials were recorded during LFS and source analysis was carried out.ResultsIpsilateral midcingulate and operculo-insular cortex source activity declined linearly during LFS. Active LFS was associated with attenuated long-latency LEP amplitude in ipsilateral frontocentral electrodes and increased resting alpha (8–12 Hz) and beta (16–24 Hz) band power in electrodes overlying operculo-insular, sensorimotor and frontal cortical regions. Reduced ipsilateral operculo-insular cortex source activity during LFS correlated with a smaller post-treatment alpha-band power increase.ConclusionsLFS attenuated somatosensory processing both during and after stimulation.SignificanceResults further our understanding of the attenuation of somatosensory processing both during and after LFS.
Keywords:Low frequency stimulation  Long term depression  Nociception  Pain  EEG
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号