P300 latency jitter and its correlates in people with amyotrophic lateral sclerosis

ObjectivePeople with amyotrophic lateral sclerosis (ALS) can benefit from brain-computer interfaces (BCIs). However, users with ALS may experience significant variations in BCI performance and event-related potential (ERP) characteristics. This study investigated latency jitter and its correlates in ALS.MethodsElectroencephalographic (EEG) responses were recorded from six people with ALS and nine neurotypical controls. ERP amplitudes and latencies were extracted. Classifier-based latency estimation was used to calculate latency jitter. ERP components and latency jitter were compared between groups using Wilcoxon rank-sum tests. Correlations between latency jitter and each of the clinical measures, ERP features, and performance measures were investigated using Spearman and repeated measures correlations.ResultsLatency jitter was significantly increased in participants with ALS and significantly negatively correlated with BCI performance in both ALS and control participants. ERP amplitudes were significantly attenuated in ALS, and significant correlations between ERP features and latency jitter were observed. There was no significant correlation between latency jitter and clinical measures.ConclusionsLatency jitter is increased in ALS and correlates with both BCI performance and ERP features.SignificanceThese results highlight the associations of latency jitter with BCI performance and ERP characteristics and could inform future BCI designs for people with ALS.