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Vancomycin-Variable Enterococcus faecium: In Vivo Emergence of Vancomycin Resistance in a Vancomycin-Susceptible Isolate |
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| Authors: | Bryan Coburn Donald E. Low Samir N. Patel Susan M. Poutanen Dea Shahinas Alireza Eshaghi Barbara M. Willey Allison McGeer |
| Affiliation: | aDivision of Infectious Diseases, Department of Medicine, University of Toronto, Toronto, Canada;bDepartment of Microbiology, University Health Network/Mount Sinai Hospital, Toronto, Canada;cDivision of Medical Microbiology, Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada;dPublic Health Ontario, Public Health Laboratory, Toronto, Canada |
| Abstract: | We report the emergence of vancomycin resistance in a patient colonized with a vanA-containing, vanRS-negative isolate of Enterococcus faecium which was initially vancomycin susceptible. This is a previously undescribed mechanism of drug resistance with diagnostic and therapeutic implications. |
| Keywords: | |