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| 血脑屏障与阿尔茨海默病的发病及防治 | |
| 引用本文： | 于艳,周亮,徐风,韩鸿滨,樊东升,崔德华.血脑屏障与阿尔茨海默病的发病及防治[J].神经疾病与精神卫生,2008,8(6):411-413. |
| 作者姓名： | 于艳 周亮 徐风 韩鸿滨 樊东升 崔德华 |
| 作者单位： | 1. 北京大学神经科学研究所神经生物国家重点学科教育部卫生部神经生物重点室验室,100191 2. 北大放射线科 3. 北大三院神经内科 4. 100191,北京大学神经科学研究所神经生物国家重点学科教育部卫生部神经生物重点室验室;北大三院神经内科 |
| 基金项目： | 国家自然基金 ， 科技部 |
| 摘 要： | 阿尔茨海默病以脑内Aβ水平升高为特征。Aβ具有神经毒性和血管毒性。血脑屏障可以调节脑内Aβ的代谢,并且通过转运体转运Aβ的跨血脑屏障转运。本文简要介绍了血脑屏障的结构和生理功能,说明了血脑屏障与阿尔茨海默病的相关性,进而探讨了AD与BBB的临床药理和治疗研究。 |
| 关 键 词： | 血脑屏障 阿尔茨海默病 |
Role of the blood-brain barrier in the pathogenesis of Alzheimer's disease |
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| Yu Yan,Zhou Liang,Xu Feng,et al..Role of the blood-brain barrier in the pathogenesis of Alzheimer''s disease[J].Nervous Diseases and Mental Health,2008,8(6):411-413. | |
| Authors: | Yu Yan Zhou Liang Xu Feng |
| Institution: | Yu Yan,Zhou Liang,Xu Feng,et al. Dep.of Neurobiology,Key Laboratory for Neuroscience Ministry of Education,Key Laboratory for Neuroscience Ministry of Public Health,Peking University Health Science Center,Beijing 100191,China |
| Abstract: | Alzheimer＇s disease （AD） is characterized by elevated levels of amyloid β-peptide（Aβ） in the brain that are associated with neuronal toxicity and vascular toxicity . The blood-brain barrier （BBB） is critical for brain Aβhomeostasis and regulates Aβ transport via two main receptors. In addition, BBB dysfunction has been observed in AD. Here we briefly review the structure and function of BBB,and then explain its association with AD . We also summarize recent clinical therapeutics based on BBB for the treatment of AD. |
| Keywords: | Blood brain barrier Alzheimer\'s disease |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |