红毛五加总甙的镇痛作用

红毛五加甙（ＴＧＡ，ｉｇ２００－８００ｍｇ·ｋｇ－１）能显著抑制小鼠热板、扭体、嘶叫反应及大鼠甩尾反应。连续给药７ｄ，镇痛作用无耐受现象。小鼠和大鼠ｉｃｖ２０ｍｇ（相当ｉｇ有效剂量的１／１０，可明显提高其痛阈。纳洛酮（２ｍｇ·ｋｇ－１）、利血平（４ｍｇ·ｋｇ－１）不影响ＴＧＡ的镇痛作用。ＴＧＡ还能明显降低大鼠足跖炎症组织中ＰＧＥ的含量。结果提示，ＴＧＡ具有镇痛作用，其作用部位可能在中枢，但可能不是通过兴奋阿片受体或影响脑内单胺类递质而发挥作用的；对ＰＧＥ含量的影响，可能是ＴＧＡ发挥镇痛作用的外周因素

ANALGESIC EFFECT OF TOTAL GLUCOSIDES OF ACANTHOPANAX GIRALDII HARMS

Acanthopanax giraldii harms, a traditional Chinese herb, had been proved to possess analgesic effect. In this study, the total glucosides of acanthopanax giraldii harms (TGA) was used to investigate the postulated effect. TGA suppressed writhing, squeak and hot plate reaction of mice and tail flicking reaction of rats, at dose of 200-800 mg·kg-1. The peak time was 1.0-1.5 hours after drug administration. Results suggested that TGA possess analgesic effect. No tolerance of analgesic effect was found after daily ig administration of TGA 400 mg·kg-1 for 7 days in mice assayed with hot plate method. The pain threshold of rats and mice was elevated after icv TGA in a dose of 1/10 systemic effective dose. However, naloxone(2 mg·kg-1) and reserpine(4 mg·kg-1) didn't block TGA'analgesic effect. These results suggested that the site of analgesic action of TGA may be in the central nervous system, the opiate receptor and monoamine transmitters in the brain seem not to be involved in the analgesic action of TGA. It decreased the content of PGE in inflammatory tissue of rats. This action of TGA may play a role in the analgesic action of TGA.