Apoptosis: Decrease of hepatocyte population in mice after hyperthermia |
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| Authors: | O. P. Molodykh L. M. Nepomnyashchikh E. L. Lushnikova M. G. Klinnikova |
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| Affiliation: | (1) Laboratory of Cytology and Cell Biology, Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk |
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| Abstract: | hyperthermia caused hemodynamic disorders in the liver and degenerative and necrobiotic changes in hepatocytes of CBA mice. Total hepatocyte count decreased during restitution, this decrease being most pronounced 30 min after exposure. The number of binucleated cells also markedly decreased. The absence of necrotic changes in hepatocytes during the entire restitution period indicated their apoptotic death and elimination by macrophagal resorption. Under these conditions liver regeneration at the cellular level occured mainly via division of binucleated hepatocytes. On the other hand, proliferation of oval cells in the portal zones and their differentiation into hepatocytes were observed at certain stages of reparative regeneration of the liver. |
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| Keywords: | whole-body hyperthermia hepatocytes alkaline dissociation of tissues apoptosis |
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