| 树突状细胞在多柔比星诱导的大鼠肾纤维化模型中的作用 |
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| 引用本文： | 汪燕,王显,沈雯雯,周琪,张伯科. 树突状细胞在多柔比星诱导的大鼠肾纤维化模型中的作用[J]. 安徽医科大学学报, 2011, 46(1): 15-19 |
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| 作者姓名： | 汪燕 王显 沈雯雯 周琪 张伯科 |
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| 作者单位： | 安徽医科大学第一附属医院肾脏内科,合肥,230022;安徽医科大学第一附属医院肾脏内科,合肥,230022;安徽医科大学第一附属医院肾脏内科,合肥,230022;安徽医科大学第一附属医院肾脏内科,合肥,230022;安徽医科大学第一附属医院肾脏内科,合肥,230022 |
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| 摘 要： | 目的 以多柔比星诱导肾纤维化大鼠为对象,探讨树突状细胞(DC)在慢性肾纤维化启动过程中的作用.方法 52只大鼠随机分为:对照组(n=20)、模型组(n=32).于第1、2周第1天给予多柔比星(4 mg/kg)尾静脉注射建立肾纤维化模型,对照组给予等量生理盐水,首次给药后第4、7、10、13周末收集血、尿标本,测定血甘油...
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| 关 键 词： | 树突细胞 多柔比星 蛋白尿 |
The effect of dendritic cell in the rats with renal fibrosis induced by Doxorubicin |
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| Wang Yan,Wang Xian,Shen Wenwen,et al. The effect of dendritic cell in the rats with renal fibrosis induced by Doxorubicin[J]. Acta Universitis Medicinalis Anhui, 2011, 46(1): 15-19 |
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| Authors: | Wang Yan Wang Xian Shen Wenwen et al |
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| Affiliation: | Wang Yan,Wang Xian,Shen Wenwen,et al(Dept of Nephrology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022) |
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| Abstract: | Objective To study the effect of dendritic cell(DC) in the startup procedure of chronic renal fibrosis by Doxorubicin-induced nephropathy.Methods 52 rats were divided into normal control group(n=20)and model group(n=32),model group was induced by tail intravenous injection of Doxorubicin(4 mg/kg)for two times at the 1st day of week 1,2,while control group received normal saline,blood and urine specimen were collected at week 4,7,10 and 13 respectively,the amount of serum triglycerides,total cholesterol,albu... |
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| Keywords: | dendritic cell Doxorubicin proteinuria |
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