同型半胱氨酸、抗心磷脂抗体与脑血栓形成的相关性研究

目的探讨同型半胱氨酸（Hcy）、抗心磷脂抗体（ACA）对脑血栓形成（CT）的发生及Hcy与叶酸（FA）、VitB12缺乏之间的关系。方法采用循环酶法测定Hcy,电化学发光免疫法检测FA、VitB12,酶联免疫吸附法（ELISA）检测ACA（IgG、IgM型）水平。结果①初发组和复发组CT患者Hcy水平显著高于对照组（P〈0.01）;FA、VitB12水平显著低于对照组;两组CT患者Hcy水平与FA、VitB12浓度均呈负相关。②初发组和复发组CT患者ACA阳性率显著高于对照组,并且两组CT患者中ACA阳性组Hcy水平显著高于ACA阴性组（P〈0.01）。结论高同型半胱氨酸血症（HHM）和ACA阳性均系CT发生的危险因素;ACA阳性可能是CT的独立危险因素之一;Hcy和ACA与CT发生有密切关系,两者相互影响,可能存在协同作用。

The correlation between homocysteine,anticardiolipin antibodies and cerebral thrombosis

Objective To investigate the relationship between homocysteine(Hcy),anticardiolipin antibodies(ACA) and the occurrence of cerebral thrombosis(CT),and to study the relationship between Hcy and the deficiency of folic acid(FA),VitB12.Methods Hcy was measured by enzymatic cycling assay,FA,VitB12 was measured by electrochemiluminescence immunoassay,and ACA(IgG,IgM type) was measured by enzyme-linked immunosorbent assay(ELISA).Results ①Compared with the control group,the Hcy level of first and recurrent group was significantly higher(P<0.01);and the level of FA,VitB12 in patients of first and recurrent group were significantly lower;the relationship between FA,VitB12 and Hcy in first and recurrent group were negatively correlated.②Compared with the control group,the positive rate of ACA of first and recurrent group was significantly higher;the Hcy level of ACA-positive patients in first and recurrent group was significantly higher than the Hcy level of ACA-negative patients(P<0.01).Conclusion Hyperhomocysteinemia(HHM) and the ACA-positive were risk factors in the occurrence of CT;ACA-positive may be an independent risk factor of CT;there is close relationship between Hcy,ACA and the occurrence of CT,they influence each other and educe synergistic effect.