静脉丙种球蛋白在新生儿ABO溶血病中的疗效观察

目的 探讨大剂量丙种球蛋白(intravenous immunoglobulin,IVIG)在新生儿溶血病(ABO血型不合)中的疗效观察.方法 回顾性分析确诊新生儿ABO溶血病120例,A组(23例)为未给予IVIG治疗;B组(33例)在出生24 h内给予IVIG,C组(29例)在生后24～48 h内给予IVIG,D组...

Curative effect of intravenous immunoglobin on ABO hemolytic disease of the newborn

Aim To explore the curative effect of intravenous immunoglobin（IVIG）used at different time on ABO hemolytic disease of the newborn.Methods 120 cases of neonatal ABO hemolytic in our hospital were divided into two groups,control group（n=23）and therapy group（n=97）.According to different time using IVIG,when therapy group was further divided into three sub groups,Ⅰgroup not exceeding 24 hours after born,Ⅱgroup between 24 hours and 48 hours,Ⅲ group over 48 hours（not exceeding 96 hours）.Common clinical data（gestational age,sex,birth weight,blood type constituent ratio,et al）,the level of serum bilirubin and hemoglobin,and time of phototherapy and hospital days were analyzed.Results There were no significant differencesin gestational age,sex,birth weight,blood type constituent ratio and other common clinical data（P0.05）.But the changes of serum bilirubin and hemoglobin,phototherapy persistence time and hospital days had significant differences in two groups（P0.01）.Three cases had exchange transfusion therapy in the end in control group,but nobody in therapy group（P0.01）.There were significant differences in changes of serum bilirubin and hemoglobin,phototherapy persistence time and hospital days between Ⅰgroup and Ⅱgroup（P0.01）.Changes of serum bilirubin between Ⅱgroup and Ⅲgroup have differences（P0.05）,but there were no significant differences in the change of hemoglobin,phototherapy persistence time and hospital days.Conclusion IVIG can quickly reduce serum billirubin,phototherapy persistence time and hospital days,and at the same time control the degree of anaemia.And intravenous IVIG used within 24 hours after birth can have well curative effect.