| 比色法测定丙戊酸镁微丸的溶出度研究 |
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| 引用本文： | 薛云琴,蒋曙光,周建平.比色法测定丙戊酸镁微丸的溶出度研究[J].安徽医药,2011,15(5):559-561. |
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| 作者姓名： | 薛云琴 蒋曙光 周建平 |
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| 作者单位： | 中国药科大学,江苏,南京,210009;中国药科大学,江苏,南京,210009;中国药科大学,江苏,南京,210009 |
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| 基金项目： | "重大新药创制"科技重大专项新制剂与新释药系统技术平台资助 |
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| 摘 要： | 目的 采用比色法测定丙戊酸镁微丸的溶出度.方法 利用镁离子与偶氮氯膦Ⅰ形成稳定的络合物,确定适宜的测定条件,建立丙戊酸镁体外测定方法.结果 镁离子与偶氮氯膦Ⅰ在pH=10.0的氨性缓冲液环境中,形成稳定的紫红色络合物,该络合物在574 nm波长处有最大吸收.供试品中镁离子浓度在2.5～25.0 mg·L-1 范围内与吸...
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| 关 键 词： | 丙戊酸镁 微丸 溶出度 偶氮氯膦Ⅰ 比色法 |
Determination of the dissolution of Magnesium valproate pellets by colorimetry |
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| XUE Yun-qin,JIANG Shu-guang,ZHOU Jian-ping.Determination of the dissolution of Magnesium valproate pellets by colorimetry[J].Anhui Medical and Pharmaceutical Journal,2011,15(5):559-561. |
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| Authors: | XUE Yun-qin JIANG Shu-guang ZHOU Jian-ping |
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| Institution: | XUE Yun-qin,JIANG Shu-guang,ZHOU Jian-ping(China Pharmaceutical University,Nanjing,Jiangsu 210009,China) |
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| Abstract: | Aim To establish a method of colorimetry to determine the dissolution of Magnesium valproate pellets.Methods Mg2＋ and chlorophosphonazo-I formed stable purplish red complex with the determination of appropriate conditions,and the in vitro analytical methodology of Magnesium valproate was established.Results In pH 10 ammonia buffer solution,reagent CPA-I and Mg2＋ formed a stable purplish red complex with the maximum absorption at 574 nm.The linear range for Mg2＋ was 2.5~25.0 mg·L-1（r=0.999 7）,with the precision of RSD5% and average recovery of 100.4%~101.9%.Conclusion The colorimetric method is sensitive,accurate and easy to operate.It could be used for detecting the dissolution of Magnesium valproate pellets. |
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| Keywords: | Magnesium valproate pellet dissolution chlorophosphonazo I colorimetry |
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