| NS-398对胰腺癌细胞PCNA-1的增殖及凋亡的影响 |
| |
| 引用本文： | 杜俊,施开德.NS-398对胰腺癌细胞PCNA-1的增殖及凋亡的影响[J].安徽医学,2011,32(2):137-139. |
| |
| 作者姓名： | 杜俊 施开德 |
| |
| 作者单位： | 巢湖市第一人民医院普外科,238000 |
| |
| 摘 要： | 目的 探讨环氧合酶-α抑制剂NS-398对人胰腺癌细胞株PCNA-1的增殖抑制作用.方法 采用MTT法、流式细胞术检测NS-398对胰腺癌细胞株PCNA-1细胞增殖抑制、细胞周期及对Bcl-2蛋白表达的影响.结果 NS-398抑制胰腺癌细胞株PCNA-1的增殖活性,呈剂量依赖效应关系; NS-398可影响PCNA-1细...
|
| 关 键 词： | 环氧合酶-α 胰腺肿瘤 bcl-2 细胞凋亡 |
Effect of NS-398 on the proliferation and apoptosis of human pancreatic carcinoma cell PCNA-1 |
| |
| Du Jun,Shi Kaide.Effect of NS-398 on the proliferation and apoptosis of human pancreatic carcinoma cell PCNA-1[J].Anhui Medical Journal,2011,32(2):137-139. |
| |
| Authors: | Du Jun Shi Kaide |
| |
| Institution: | Du Jun,Shi Kaide Department of General Surgery,the First Hospital of Chaohu City,Chaohu 238000,China |
| |
| Abstract: | Objective To investigate the effects of cyclooxygenase inhibitor NS-398 on the proliferation and apoptosis of PCNA-1 and its influence of bcl-2 protein.Methods The effects of NS-398 on the proliferation of human PCNA-1was detected by MTT assay,The effects of NS-398 on the cell cycle of human PCNA-1 and the expression of apoptosis associated protein bcl-2 were detected by flow cytometry.Results NS-398 inhibit the proliferation of human PCNA-1 as dose-dependent effect,NS-398 can influence the cell cycle;dealt... |
| |
| Keywords: | bcl-2 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
