| HLA-DRB1等位基因及抗CCP抗体与类风湿关节炎骨侵蚀相关性研究 |
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| 引用本文： | 蒋真,李向培,钱龙,张宏. HLA-DRB1等位基因及抗CCP抗体与类风湿关节炎骨侵蚀相关性研究[J]. 安徽医药, 2011, 15(5): 587-589 |
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| 作者姓名： | 蒋真 李向培 钱龙 张宏 |
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| 作者单位： | 南京医科大学附属淮安市第一人民医院免疫风湿科,江苏,淮安,223300;安徽省立医院风湿科,安徽,合肥,230000 |
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| 基金项目： | 安徽省自然科学基金资助项目 |
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| 摘 要： | 目的探讨HLA-DRB1等位基因和抗CCP抗体的相关性及两者对类风湿关节炎(Rheum atoid Arthritis,RA)关节破坏严重性的影响。方法采用SSP(序列特异性引物)多重PCR技术扩增病例组(106例)与对照组(340例)HLA-DRB1等位基因;采用酶联免疫吸附试验(ELISA)检测抗CCP抗体;同时采集RF、ESR、CRP、关节X线表现分期和病程等资料。以卡方检验分析HLA-DRB1等位基因与抗CCP抗体的相关性;以关节X线表现作为关节破坏程度的指标(为应变量),各HLA-DRB1等位基因、抗CCP抗体、病程等为自变量,以Logistic回归分析的方法分析X线表现与上述各自变量的相关性。结果 SE等位基因与抗CCP抗体的产生有显著相关性(P=0.043)。多因素分析表明以关节X线表现为应变量,HLA-DRB1*0405、病程和CRP与X线表现呈正相关。结论 HLA-DRB1等位基因对RA的影响是多方面的,即影响RA的发病易感性,也影响其病情严重性,并且与抗CCP抗体的产生显著相关。
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| 关 键 词： | 关节炎 类风湿 HLA-DRB1等位基因 抗CCP抗体 严重性 |
Influences of HLA-DRB1 alleles and anti-CCP antibody on the arthrosis erosion of rheumatoid arthritis |
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| JIANG Zhen,LI Xiang-pei,QIAN Long,ZHANG Hong. Influences of HLA-DRB1 alleles and anti-CCP antibody on the arthrosis erosion of rheumatoid arthritis[J]. Anhui Medical and Pharmaceutical Journal, 2011, 15(5): 587-589 |
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| Authors: | JIANG Zhen LI Xiang-pei QIAN Long ZHANG Hong |
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| Affiliation: | 1.Department of Rheumatology ﹠ Immunology,The Affiliated First People＇s Hospital of Huaian,Nanjing Medical University,Huaian 223300,China;2.Department of Rheumatology,Anhui Provincical Hospital,Hefei 230000) |
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| Abstract: | Aim To explore the correlation between anti-CCP antibody and HLA-DRB1 alleles and explore the influence of the two factors on the arthrosis erosion of Rheumatoid Arthritis(RA).Methods Multiple sequence specific primer PCR(SSP-PCR)was used to amplify HLA-DRB1 alleles of RA(106 patients)and normal control groups(340 patients);enzyme linked immunosorbent assay(ELISA)was used to find anti-CCP antibody.The clinical data RF,ESR,CRP,X-ray of arthrosis,the function of arthrosis and disease course,and so onwere coll... |
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| Keywords: | arthritis rheumatoid HLA-DRB1 allele anti-CCP antibody severity |
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