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Claudin-1mRNA在肝细胞癌中的表达及临床意义
引用本文:张正东,耿小平,李晓明,赵红川,赵义军,黄帆.Claudin-1mRNA在肝细胞癌中的表达及临床意义[J].安徽医科大学学报,2011,46(2):131-134.
作者姓名:张正东  耿小平  李晓明  赵红川  赵义军  黄帆
作者单位:安徽医科大学第一附属医院肝胆外科,合肥,230022;香港中文大学病理科,香港,530020
摘    要:目的 探讨肝细胞癌(HCC)中Claudin-1 mRNA的表达与临床病理因素的关系.方法 采用实时荧光定量PCR(qRT-PCR)方法检测35例HCC组织及相应癌旁组织和10例正常肝组织中Claudin-1 mRNA的表达水平,并结合相关指标进行分析.结果 Claudin-1 mRNA在HCC组织中的表达明显低于癌旁...

关 键 词:  肝细胞  RNA  信使

Expression and significance of Claudin-1 mRNA in human hepatocellular carcinoma
Zhang Zhengdong,Geng Xiaoping,Li Xiaoming,et al.Expression and significance of Claudin-1 mRNA in human hepatocellular carcinoma[J].Acta Universitis Medicinalis Anhui,2011,46(2):131-134.
Authors:Zhang Zhengdong  Geng Xiaoping  Li Xiaoming  
Institution:Zhang Zhengdong1,Geng Xiaoping1,Li Xiaoming2,et al(1Dept of Hepatobiliary Surgery,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,2Dept of The Pathology,Hong Kong Chinese University,Hongkong 530020)
Abstract:Objective To investigate the relations between expression of Claudin-1 mRNA and clinical pathology factor in hepatocellar carcinoma(HCC).Methods Fluorescence and real-time quantitative PCR was carried out to detect the level of Claudin-1 mRNA from 35 HCC tissues and their corresponding normal tissues and 10 normal liver tissues.The significance was analyzed by those data and related clinical and pathological factors.Results Lower expression of Claudin-1 mRNA was found in tissues than that in their correspon...
Keywords:carcinoma  hepatocellular  RNA  messenger  
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