| 尼美舒利颗粒溶出度测定方法研究 |
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| 引用本文： | 孙凌云. 尼美舒利颗粒溶出度测定方法研究[J]. 安徽医药, 2011, 15(3): 300-302 |
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| 作者姓名： | 孙凌云 |
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| 作者单位： | 安徽省食品药品检验所,安徽,合肥,230051 |
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| 摘 要： | 目的研究尼美舒利颗粒溶出度。方法以磷酸盐缓冲液(pH=8.8)为溶出介质,采用篮法进行溶出度测定,转速:100 r.min-1,用紫外分光光度法在393 nm波长处测定。结果绘制的溶出曲线表明20 min内尼美舒利颗粒可溶出80%以上,确定的溶出时间30 min,限度为80%。结论测定6批样品的溶出量均符合规定。
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| 关 键 词： | 尼美舒利 颗粒剂 溶出度 |
Dissolution test of Nimesulide granules |
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| SUN Ling-yun. Dissolution test of Nimesulide granules[J]. Anhui Medical and Pharmaceutical Journal, 2011, 15(3): 300-302 |
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| Authors: | SUN Ling-yun |
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| Affiliation: | SUN Ling-yun (Anhui Provincial Institute for Food and Drug Control,Hefei 230051,China) |
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| Abstract: | Aim To study the dissolution of nimesulide granules.Methods Phosphate buffer was used（pH=8.8）as the dissolution medium and rotational speed of the basket was adjusted to 100 r·min-1.The absorbance was measured at 393 nm.Results The curve showed that nimesulide granules could dissolve 80% and upwards within 20 minutes.It was confirmed that the time of dissolution was 30 minutes and the limit was 80%.Conclusion 6 batches of samples were tested and the results met the qualification. |
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| Keywords: | nimesulide granules dissolution |
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