| 吡格列酮对血管内皮细胞及JNK信号通路的影响 |
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| 引用本文： | 张楠,丁俊,章秋,李俊. 吡格列酮对血管内皮细胞及JNK信号通路的影响[J]. 安徽医科大学学报, 2011, 46(2): 150-153 |
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| 作者姓名： | 张楠 丁俊 章秋 李俊 |
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| 作者单位： | 安徽医科大学第一附属医院内分泌科,合肥,230022;安徽医科大学药学院,合肥,230032 |
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| 摘 要： | 目的 探讨吡格列酮(PIO)对血管内皮细胞的保护作用及其可能机制.方法 用四唑盐比色法(MTT法)检测PIO对高糖损伤血管内皮细胞的最佳保护浓度;按不同干预条件,将血管内皮细胞分为7组:正常培养组[A组,葡萄糖(Glu) 5.5 mmol/L],高糖培养组(B组,Glu 37.5 mmol/L),C、D、E组分别为不同...
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| 关 键 词： | 噻唑烷二酮类 信号传导 糖尿病 |
The effects of pioglitazone on vascular endothelial cell and c-Jun N-terminal kinase signalling pathway |
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| Zhang Nan,Ding Jun,Zhang Qiu,et al. The effects of pioglitazone on vascular endothelial cell and c-Jun N-terminal kinase signalling pathway[J]. Acta Universitis Medicinalis Anhui, 2011, 46(2): 150-153 |
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| Authors: | Zhang Nan Ding Jun Zhang Qiu et al |
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| Affiliation: | Zhang Nan,Ding Jun,Zhang Qiu,et al(Dept of Endocrinology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022) |
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| Abstract: | Objective To investigate the protective effect and possible mechanism of pioglitazone(PIO) on vascular endothelial cell.Methods The optimum concentration of PIO played a protective role on cells which was assessed by MTT assay.The vascular endothelial cells were randomly divided into 7 groups,normal culture group [group A,glucose(Glu) 5.5mmol/L],cultured in high glucose group(group B,Glu 37.5 mmol/L),the cells in group C,D and E were cultured in PIO(with different concentration)+ high glucose,and group F an... |
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| Keywords: | thiazolidinediones signal transduction diabetes mellitus |
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