人参总皂苷对四氯化碳诱导的大鼠肝纤维的保护作用

目的 观察人参总皂苷(缓控 of panax ginseng,SPG)对四氯化碳所诱导的肝纤维化大鼠的保护作用.方法 将大鼠随机分为正常组、模型组、人参总皂苷40、80、160 mg·kg-1组,阳性药秋水仙碱0.1 mg·kg-1组.除正常组外,其余各组采用四氯化碳诱导肝纤维化模型.于造模第7周起,给药组分别灌胃给予...

Protective effect of saponins of panax ginseng on carbon tetrachloride-induced hepatic fibrosis rats

Aim To observe the protective effect of saponins of panax ginseng（SPG）on carbon tetrachloride-induced hepatic fibrosis rats.Methods Rat liver fibrosis model was established by subcutaneous injection（s.c.）of 50%CCl4 twice a week lasting for 12 weeks.SPG（40,80,160 mg·kg-1）was treated gastrogavage（ig）daily since the 7th week.Contents of ALT,AST,MDA and SOD were determined by absorption spectrometry;HA,LN,PCⅢ and CIV level in serum were determined by radioimmunity.Hepatic tissues stained with hematoxylin and eosin（HE）were prepared for histological analysis to liver injury.CTGFmRNA expression in liver tissue was detected by RT-PCR technology.Results Compared with model group,SPG（40,80,160 mg·kg-1）significantly decreaied ALT,AST,HA,PCⅢ,CⅣ,MDA contents.Meanwhile,the pathological injury of hepatic tissues were revesed,and CTGF mRNA expression,while the level of SOD stepped up.Conclusion SPG has remarkable protective effects on liver fibrosis in rats.