| 外源性胰岛素对2型糖尿病大鼠抗炎及肾脏的保护作用 |
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| 引用本文： | 汝燕,李素梅,翟斐,张丽,章容.外源性胰岛素对2型糖尿病大鼠抗炎及肾脏的保护作用[J].安徽医科大学学报,2011,46(2):142-145. |
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| 作者姓名： | 汝燕 李素梅 翟斐 张丽 章容 |
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| 作者单位： | 安徽医科大学附属省立医院内分泌科,合肥,230001;安徽医科大学附属省立医院内分泌科,合肥,230001;安徽医科大学附属省立医院内分泌科,合肥,230001;安徽医科大学附属省立医院内分泌科,合肥,230001;安徽医科大学附属省立医院内分泌科,合肥,230001 |
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| 摘 要： | 目的 观察外源性胰岛素对2型糖尿病大鼠血、尿细胞间黏附分子1(ICAM-1)的表达及肾组织结构和功能的影响.方法 30只健康SPF级雄性SD大鼠,10只作为正常对照组(A组)喂饲常规饲料;20只采用喂饲高糖高脂饮食,3个月后一次性腹腔注射小剂量链脲佐菌素,建立2型糖尿病大鼠模型;模型大鼠随机分为糖尿病组(B组)和胰岛素...
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| 关 键 词： | 糖尿病 2型 糖尿病肾病/药物疗法 胰岛素/治疗应用 细胞间黏附分子1 |
The effect of exogenous insulin on anti-inflammatory and renal function of type 2 diabetic rats |
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| Ru Yan,Li Sumei,Zhai Fei,et al.The effect of exogenous insulin on anti-inflammatory and renal function of type 2 diabetic rats[J].Acta Universitis Medicinalis Anhui,2011,46(2):142-145. |
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| Authors: | Ru Yan Li Sumei Zhai Fei |
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| Institution: | Ru Yan,Li Sumei,Zhai Fei,et al(Dept of Endocrinology,The Affiliated Provincial Hospital of Anhui Medical University,Hefei 230001) |
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| Abstract: | Objective To observe the effect of exogenous insulin on the level of ICAM-1 in serum and urine and the change of renal structure and function of type 2 diabetic rats.Methods 30 healthy male SD rats of SPF grade were chosen.10 of them were randomly selected as normal group(group A) who fed with normal diet,while the others were established as type 2 diabetes rat model by using high sucrose-high fat diet and injecting low dose Streptozotocin.Then these rats were randomly divided into type 2 diabetes group(gro... |
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| Keywords: | diabetes mellitus type 2 diabetic nephropathies/durg therapy insulin/therapeutic use intercellular adhesion molecule-1 |
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