男泌清胶囊治疗慢性前列腺炎的临床与实验研究

目的 :验证男泌清胶囊 (大黄、水蛭、黄芪等 )治疗慢性前列腺炎的临床疗效及作用机理。　方法 :用男泌清胶囊治疗慢性前列腺炎 76例 ,与用前列康片治疗的 32例作对照 ,观察治疗前后前列腺液等改变情况 ;并用消痔灵制作大鼠前列腺炎病理模型 ,分别用男泌清胶囊及前列康片治疗 ,观察 2种药物用药前后大鼠前列腺病理组织学、血浆内皮素、血栓素B2和 6 酮 前列腺素F1α以及超氧化物歧化酶 (SOD)、IgG、IgA变化。　结果 :男泌清临床治疗组总有效率为 89.4 7% ,对照组为 71.88% (P <0 .0 1)。动物实验显示男泌清胶囊改善大鼠前列腺炎各项指标的作用均明显优于前列康片 (P <0 .0 1)。　结论 :临床及实验研究结果显示男泌清胶囊对慢性前列腺炎有较好治疗效果 ;提示“苦寒解毒、活血化瘀、益气扶正”为治疗慢性前列腺炎之重要治法 ,可明显改善慢性前列腺炎的症状

Clinical and Experimental Study of Treatment of Nanmiqing Capsule for Chronic Prostatitis

OBJECTIVES: To investigate the clinical effect and therapeutic mechanism of Nanmiqing capsule made of rheum palmatum, leech, astragalus memberanaceus on patients with chronic prostatitis(CP). METHODS: Seventy-six CP cases were treated with Nanmiqing, while 32 CP cases were treated with Qianliekang as a control. The changes of EPS were observed pre- and post-treatment. The rat model of CP got by Xiaozhiling inducing were treated with Nanmiqing and Qianliekang respectively. The concentration of endothelin, TXB2, 6-keto-PGF1 alpha and SOD, IgG, IgA in plasma were measured pre- and post-treatment, meanwhile, pathological changes of prostate tissues were observed. RESULTS: The total effective rate was 89.47% in treatment group, which was significantly higher than 71.88% in the control group (P < 0.01). Experimental study for CP rats showed that the Nanmiqing was more effective medicine than Qianliekang (P < 0.01). CONCLUSIONS: Nanmiqing was an effective medicine for CP. The mechanism of clearing heat and resolving toxin, activating blood and removing stasis and reinforcing Qi in chinese medicine could be the explanation of the useful treatment including three therapentic ways.