丹参对实验性急性坏死性胰腺炎的疗效及对血液流变学的影响

采用5％牛磺胆酸钠行犬胰管逆行灌注制备急性坏死性胰腺炎(ANP)模型。观察到ANP早期即出现低切变率下全血表观粘度上升、红细胞聚集性增强及红细胞变形性下降等一系列血液流变学异常。丹参治疗可显著改善上述血液流变学异常,并提高ANP犬生存率和减轻胰腺坏死程度。

Hemorheologic Effects and Therapeutic Efficacy of Salvia Miltiorrhiza in Experimental Acute Necrotizing Pancreatitis

A dog model of acute necrotizing pancreatits (ANP) was induced by injection of 5 % sodium taurocholate into the main pancreatic duct, in which the hemorheologic changes were measured and the therapeutic efficacy of salvia miltiorrhiza was evaluated. The results showed that during the early stage of ANP, red blood cells tended to aggregate with rouleaux formation, erythrocyte deformability decreased, hematocrit increased and viscosity of whole blood increased especially under low shear rate. After using salvia miltiorrhiza, the hemorheologic alterations in ANP were recovered. In addition, salvia miltiorrhiza significantly reduced the severity and mortality of ANP. These result suggested that salvia miltiorrhiza appeared to limit the progression of pancreaticnecrosis through improving the hemorheologic disturbances at the early stage of ANP. We Proposed the hemorrheologic disturbances may play a role in the pathogenesis of ANP.