Extensive genetic polymorphism in the human tumor necrosis factor region and relation to extended HLA haplotypes |
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| Authors: | C V Jongeneel L Briant I A Udalova A Sevin S A Nedospasov A Cambon-Thomsen |
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| Affiliation: | Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland. |
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| Abstract: | We have identified three polymorphic microsatellites (which we call TNFa, TNFb, and TNFc) within a 12-kilobase region of the human major histocompatibility complex (MHC) that includes the tumor necrosis factor (TNF) locus. TNFc is located within the first intron of the TNF-beta gene and has only 2 alleles. TNFa and TNFb are 3.5 kilobases upstream (telomeric) of the TNF-beta gene and have at least 13 and 7 alleles, respectively. TNFa, -b, and -c alleles are in linkage disequilibrium with alleles at other loci within the MHC, including class I, class II, and class III. TNFa, -b, and -c alleles are also associated with extended HLA haplotypes. These TNF polymorphisms will allow a thorough genetic analysis of the involvement of TNF in MHC-linked pathologies. |
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