Histopathological findings of pericarditis in a patient with multisystem inflammatory syndrome in children associated with COVID-19: A case report |
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Authors: | Kazuaki Maruyama Kazushi Yasuda Ryoichi Ito Kyoko Imanaka-Yoshida |
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Institution: | 1. Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University, Mie, Japan;2. Department of Pediatric Cardiology, Aichi Children's Health and Medical Centre, Obu, Japan |
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Abstract: | Multisystem inflammatory syndrome in children (MIS-C), which is associated with the novel coronavirus disease 2019 (COVID-19), has been described as an inflammatory complication of exposure to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It carries a risk of serious and lethal complications, including cardiogenic shock. Here, we report the pathological findings of the pericardium in a 10-year-old child with MIS-C, who developed pericarditis-induced cardiac tamponade. In the patient's pericardium, the numbers of infiltrating CD68+ macrophages; CD3+, CD4+, and CD8+ T cells; and myeloperoxidase+ granulocytes were increased, although the number of CD20+ B cells was not. These findings provide a clue to understanding the pathophysiology of MIS-C. |
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Keywords: | cardiac tamponade MIS-C pericarditis SARS-CoV-2 |
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