Dyslipdemia induced by chronic low dose co-exposure to lead,cadmium and manganese in rats: the role of oxidative stress |
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| Institution: | 1. Biochemistry Division, National Veterinary Research Institute, P.M.B. 01, Vom, Nigeria;2. Department of Veterinary Pharmacology & Toxicology, Ahmadu Bello University, Zaria, Nigeria;3. Department of Veterinary Physiology, Ahmadu Bello University, Zaria, Nigeria;4. Department of Veterinary Pharmacology & Toxicology, University of Ilorin, Ilorin, Nigeria;5. Department of Veterinary Pathology, Ahmadu Bello University, Zaria, Nigeria;1. Pinderfields Hospital, Mid Yorkshire NHS Trust, Wakefield, United Kingdom;2. Sheffield Teaching Hospitals NHS Foundation Trust, United Kingdom;1. Department of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China;2. Department of Public Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;1. Laboratory of Clinical & Experimental Toxicology and Poison Control Center, Toxicology Unit, IRCCS Salvatore Maugeri Foundation and University of Pavia, Pavia, Italy;2. N.A.M Srl, NANO-Analysis & Materials, Pavia, Italy;1. Boston Combined Residency Program in Pediatrics, Boston Children''s Hospital/Boston Medical Center, Boston, Mass;2. Department of Pediatrics, Boston Medical Center, Boston, Mass;3. Department of Medicine, Boston Children''s Hospital, Boston, Mass;4. Department of Research, American Academy of Pediatrics, Elk Grove Village, Ill;1. Benaroya Research Institute at Virginia Mason, Seattle, Wash;2. University of Washington School of Medicine, Seattle, Wash;1. Department of Occupational Health and Toxicology, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China;2. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, PR China;3. Department of Anatomy, School of Medicine, Nanchang University, BaYi Road 461, Nanchang 330006, PR China;4. Department of Medical Experiment Teaching, School of Public Health, Nanchang University, BaYi Road 461, Nanchang 330006, PR China |
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| Abstract: | Lead (Pb), cadmium (Cd) and manganese (Mn) have many potential adverse health effects in vitro and in animal models of clinical toxicity. The current study investigated the dyslipidaemic and oxidative stress effects of chronic low-dose oral exposure to Pb, Cd and Mn and the combination (Pb + Cd + Mn) in rats for 15 weeks. Chronic exposure to the metals did not significantly (P > 0.05) alter serum lipid profiles. However, the atherogenic index decreased by 32.2% in the Pb + Cd + Mn group, relative to the control. The triglyceride/high-density lipoprotein cholesterol ratio decreased by 39.4% in the Pb + Cd + Mn group, relative to the control, and elevated by 81.8, 94.8 and 20.8%, relative to the Pb, Cd and Mn groups, respectively. While the serum concentrations of malondialdehyde significantly increased in the Mn and Pb + Cd + Mn groups, that of glutathione peroxidase-1 decreased in the Pb + Cd + Mn group, and metallothionein-1 and zinc concentrations markedly decreased in all the metal treatment groups.The results suggest that long-term exposure of rats to Pb + Cd + Mn may result in hypolipidaemia, mediated via oxidative stress and metal interactions. Individuals who are constantly exposed to environmentally relevant levels of the metals may be at risk of hypolipidaemia. |
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| Keywords: | Lead cadmium manganese zinc hypolipidaemia oxidative stress |
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