Toxicity and accumulation of Copper oxide (CuO) nanoparticles in different life stages of Artemia salina |
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| Affiliation: | 1. Instituto de Ciências do Mar, LABOMAR/UFC, 60165-081 Fortaleza, Ceará, Brazil;2. Department of Biology and CESAM, University of Aveiro, 3810-193 Aveiro, Portugal;1. Institute for Environmental Protection and Research, Via Brancati 60, 00144 Rome, Italy;2. University of Genoa, Corso Europa, 16146 Genoa, Italy;3. Institute of Marine Science, National Council of Researches (CNR), Via De Marini 6, 16149 Genoa, Italy;1. Biotechnical Faculty, University of Ljubljana, Večna pot 111, 1000 Ljubljana, Slovenia;2. National Institute of Chemical Physics and Biophysics, Laboratory of Environmental Toxicology, Akadeemia tee 23, 12618 Tallinn, Estonia;3. The Centre for Cellular & Molecular Biology, Habsiguda, Hyderabad, Telangana 500007, India;4. Faculty of Chemistry and Chemical Technology, University of Ljubljana, Večna pot 113, 1000 Ljubljana, Slovenia;5. Helmholtz-Centre for Environmental Research – UFZ, Department of Bioanalytical Ecotoxicology, Permoserstr. 15, 04318 Leipzig, Germany;1. Department of Environmental Sciences, Informatics and Statistics, University Ca’ Foscari Venice, Via Torino 155, 30172 Mestre, Venice, Italy;2. Institute for the Coastal Marine Environment, National Research Council (CNR IAMC), Via Roma 3, 74100 Taranto, Italy;3. Department of Biology, University Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy;4. Italian Institute for Environmental Protection and Research, Via Vitaliano Brancati 60, 00144 Rome, Italy;5. Stazione Zoologica Anton Dohrn, Villa Comunale, 80121 Naples, Italy;1. Shenzhen Key Laboratory of Organic Pollution Prevention and Control, State Key Laboratory of Urban Water Resource and Environment of Harbin Institute of Technology (Shenzhen), 518055, China;2. Graduate School at Shenzhen, Tsinghua University, Shenzhen, China;3. Tianjin Key Laboratory of Marine Resources and Chemistry, College of Marine and Environmental Sciences, Tianjin University of Science and Technology, Tianjin, China;4. Department of Biological and Environmental Engineering, Changsha University, Changsha 410003, China;1. Faculty of Marine Science and Technology, University of Hormozgan, Bandar Abbas, Iran;2. Fisheries Department, Faculty of Natural Resources, University of Kurdistan, ZIP Code: 66177-15175, P.O. Box 416, Sanandaj, Iran;3. Department of Nano Bio Technology, Hoseo University, Asan, Republic of Korea;4. Department of Nanofusion Technology, Hoseo University, Asan, Republic of Korea;5. HCTm CO., LTD., Icheon, Republic of Korea |
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| Abstract: | Metal nanoparticles production rate and its applications have raised concerns about their release and toxicity to the aquatic and terrestrial organisms. The primary size of Copper Oxide nanoparticles (CuO NP’s) was found to be 114 ± 36 nm using Scanning Electron Microscopy (SEM) and a significant increase in the hydrodynamic diameter of CuO NP was seen within 1 h of interaction. The median lethal concentration (LC50) values obtained from the acute toxicity studies on different life stages of Artemia salina was found to be 61.4, 35, 12.2 and 175.2 mg/L for 1d, 2d, 7d old and adult, respectively. The toxicity associated changes in biochemical markers such as Catalase, Reduced glutathione and Glutathione-S-Transferase were evident. The accumulation of Cu nanoparticles into the gut of Artemia salina was the major reason for toxicity. This study demonstrate the toxicity of CuO NPs to Artemia salina, and the obtained results necessitate the detailed investigation on the possible eco-toxicological implication of these nanomaterials. |
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| Keywords: | Copper oxide NPs Particle stability Bioaccumulation Biochemical markers |
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