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SARS-CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10 |
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| Authors: | André M. C. Gomes Guilherme B. Farias Manuel Dias-Silva Joel Laia Amelia C. Trombetta Ana Godinho-Santos Pedro Rosmaninho Diana F. Santos Carolina M. Conceição Renato Costa-Reis Maria Adão-Serrano Catarina Mota Afonso R. M. Almeida Ana E. Sousa Susana M. Fernandes |
| Affiliation: | 1. Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal Clínica Universitária de Medicina Intensiva, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal;2. Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal;3. Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal Centre for Ecology, Evolution and Environmental Changes, Faculdade de Ciências, Universidade de Lisboa, Lisboa, 1749-016 Portugal;4. Serviço de Medicina Intensiva, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal;5. Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal Serviço de Medicina Intensiva, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal;6. Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Lisboa, Portugal Serviço de Medicina II, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte, Lisboa, Portugal |
| Abstract: | Accelerate lung repair in SARS-CoV-2 pneumonia is essential for pandemic handling. Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and tissue homeostasis. We studied ILC subpopulations at two time points in a cohort of patients admitted in the hospital due to SARS-CoV-2 infection. COVID-19 patients with moderate/severe respiratory failure featured profound depletion of circulating ILCs at hospital admission, in agreement with overall lymphocyte depletion. However, ILCs recovered in direct correlation with lung function improvement as measured by oxygenation index and in negative association with inflammatory and lung/endothelial damage markers like RAGE. While both ILC1 and ILC2 expanded, ILC2 showed the most striking phenotype changes, with CCR10 upregulation in strong correlation with these parameters. Overall, CCR10+ ILC2 emerge as relevant contributors to SARS-CoV-2 pneumonia recovery. |
| Keywords: | COVID-19 SARS-CoV2 Lung recovery Innate lymphoid cells CCR10 |