Cyanidin-3-rutinoside increases glucose uptake by activating the PI3K/Akt pathway in 3T3-L1 adipocytes |
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| Affiliation: | 1. Department of Food Science and Nutrition, and Research Institute of Ecology for the Elderly, Pusan National University, Busan 609-735, Republic of Korea;2. Department of Food and Nutrition, College of Medical and Life Science, Silla University, Busan 616-735, Republic of Korea;1. Department of Traditional Chinese Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China;2. Department of Pathology, Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine, Wenzhou, China;1. Key Laboratory of Human Functional Genomics of Jiangsu Province, Nanjing Medical University, Nanjing, 211166, China;2. Department of Endocrinology, Second Hospital of Shanxi Medical University, Taiyuan, 030001, China;3. Department of Endocrinology, Zhangzhou Municipal Hospital Affiliated to Fujian Medical University, Zhangzhou, 363000, China;4. Department of Endocrinology, Shanxi Academy of Medical Sciences & Shanxi Bethune Hospital, Taiyuan, 030001, China;5. Department of Pathology, Nanjing Medical University, Nanjing, 211166, China;6. Department of Pathology and Clinical Laboratory, Sir Run Run Hospital of Nanjing Medical University, Nanjing, 211166, China;1. Key Provincial Laboratory of Basic Pharmacology, Nanchang University, Nanchang 330006, Jiangxi Province, P.R. China;2. Department of Pharmacology, School of Pharmaceutical Science, Nanchang University, Nanchang 330006, Jiangxi Province, P.R. China;3. Jiangxi Medical School, Nanchang University, Nanchang 330006, Jiangxi Province, P.R. China;1. National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng, 475004, China;2. Joint International Research Laboratory of Food & Medicine Resource Function, Henan Province, Henan University, Kaifeng, 475004, China;3. Kaifeng Key Laboratory of Functional Components in Health Food, Kaifeng, 475004, China |
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| Abstract: | In this study, the effect of cyanidin-3-rutinoside (C3R) on glucose uptake by 3T3-L1 adipocytes was studied. C3R significantly increased glucose uptake, which was associated with enhanced plasma membrane glucose transporter type 4 (PM-GLUT4) expression in 3T3-L1 adipocytes. The potentiating effect of C3R on glucose uptake and PM-GLUT4 expression was related to enhanced phosphorylation of insulin receptor substrate 1 (IRS-1) and Akt, as well as augmented activation of phosphatidylinositol-3-kinase (PI3K) in the insulin signaling pathway. C3R induced glucose uptake was inhibited only by the PI3K inhibitor, but not by an AMPK inhibitor in 3T3-L1 adipocytes. Therefore, C3R likely up-regulates glucose uptake and PM-GLUT4 expression in 3T3-L1 adipocytes by activating the PI3K/Akt pathways. |
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| Keywords: | Cyanidin-3-rutinoside Glucose uptake PI3K/Akt pathway 3T3-L1 adipocyte |
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