Protective effect of ferulic acid on cisplatin induced nephrotoxicity in rats |
| |
| Affiliation: | 1. Medicinal Chemistry and Pharmacology Division, Indian Institute of Chemical Technology (IICT), Hyderabad 500 007, India;2. National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad 500 037, India;3. National Centre for Mass Spectrometry, Indian Institute of Chemical Technology (IICT), Hyderabad 500 007, India;4. CSIR-Centre for Cellular and Molecular Biology (CCMB), Hyderabad 500 007, India;5. Faculty of Pharmacy, Osmania University, Hyderabad 500 007, India |
| |
| Abstract: | This study aims to determine the potential protective effects of ferulic acid against cisplatin-induced nephrotoxicity and to compare its effect with curcumin, a well-known protective agent against cisplatin- induced toxicity in rats. Administration of cisplatin resulted in high BUN (Blood Urea Nitrogen), creatinine, MDA (Malondialdehyde), MPO (Myeloperoxidase), TOS (Total Oxidative Status), PtNT (Protein Nitrotyrosine) levels (p < 0.05). Histological observations showed abnormal morphology of kidney; in addition with appearance of TUNEL positive cells indicating apoptosis in cisplatin administered group. HO-1 (Heme Oxygenase-1) levels measured by RT-PCR (Real Time Polymerase Chain Reaction), and TAS (Total Antioxidative Status) revealed antioxidant depletion due to cisplatin toxicity in animals (p < 0.05). All parameters showed improvement in groups treated with ferulic acid (p < 0.05). Ferulic acid treatment was found significant in preventing oxidative stress, increasing antioxidative status and regaining histological parameters to normal, indicating nephroprotective and antioxidant effects of this phenolic compound. |
| |
| Keywords: | Kidney Cisplatin Ferulic acid Curcumin |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
