Chemotaxis of peripheral blood leukocytes in patients with diffuse purulent peritonitis

Leukocytic chemotaxis was evaluated in 43 patients with diffuse purulent peritonitis. It was found out that time course changes in chemotactic activity of leukocytes have a phasic pattern: it was reduced in an early postoperative period, there is a tendency to enhancement of cellular spontaneous and target migration 3-6 days after operation and onwards, maximal response to chemotactic stimulus on day 7-14 after operative intervention. Postoperative serum factors show a diverse influence on leukocytic chemotaxis. Correlation observed between chemotaxic activity and postoperative developments allows the author to propose an assessment of leukocytic chemotaxis in patients with diffuse purulent peritonitis on follow-up to diagnose early complications and to control immunocorrective therapy administered.