2型糖尿病血管并发症患者血脂及血浆NO水平的临床研究

目的:评价2型糖尿病(DM)血管并发症患者血脂及血浆NO水平的状况。方法:对203例临床诊断为2型DM的住院患者(男性103例,女性100例)的空腹血脂及血浆NO水平做出分析。结果:A组总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、载脂蛋白A1、载脂蛋白B及NO分别为:(4.83±0.87)mmol/L,(2.67±0.42)mmol/L,(1.75±0.65)mmol/L,(1.53±0.19)g/L,(0.88±0.17)g/L及(8.12±1.96)mmol/L。A组高密度脂蛋白胆固醇(HDL-C)的均值为(1.34±0.18)mmol/L,高于C组(P<0.01),NO降低的检出率B组高于C组(P<0.01),血浆NO水平较差的C组显著低于A组(P<0.01)。结论:2型DM患者血糖的控制程度会导致其血脂及NO水平的差异,血糖控制较差会导致血脂代谢紊乱程度增加,并使NO生成减少,要防止血管并发症的发生应该重视及时评价糖代谢问题。

Clinical Research on the Levels of Blood-Lipid and Plasma Monoxide Nitrogen in Type II Diabetes Mellitus Patients with Vascular Complications

Objective:To evaluate the significance of the levels of blood-lipid and plasma monoxide nitrogen(NO) in type II diabetes mellitus(DM) patients with vascular complications.Methods：A total of 203 inpatients (103 male, 100 female) clinically diagnosed type II DM were inrolled in this study. The level of fasting blood- lipid and plasma NO were examined and analyzed.Results：The level of total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),triglyceridemia(TG),apolipoprotein A1(ApoA1),apolipoprotein B(ApoB)and NO was(4.83±0.87)mmol/L,(2.67±0.42)mmol/L,(1.75±0.65)mmol/L,(1.53±0.19)g/L,(0.88±0.17)g/L and(8.12±1.96)mmol/L in group A,respectively.The mean level of HDL-C was(1.34±0.18)mmol/L in group A, higher than that of group C(P＜0.01).The detectable rate of reduced NO was higher in group B than that in group C(P＜0.01).Group C,which had worse level of plasma NO,was significantly lower than group A(P＜0.01).Conclusion：In type II DM patients,the level of blood glucose can affect the level of blood-lipid and plasma NO. Bad controlled blood glucose increases the disturbance of lipid metabolism and reduces plasma NO. Preventing vascular complications should attach importance to the evaluation of glycometabolism timely.