FOLFOX4方案二线治疗晚期胃癌临床疗效观察

目的观察草酸铂（L—OHP）联合亚叶酸钙（CF），5-氟尿嘧啶（5-Fu）治疗晚期胃癌的近期疗效及毒副反应。方法确诊晚期胃癌患者32例，均为先前行DF、ECF方案治疗失败的患者，治疗方案为：L—OHP 85mg／m^2 iv gtt，h 0-2，d1；CF 200mg／m^2，iv gtt，2h，d1-2；5-Fu 400mg／m^2，iv bolus 2h，d1-2；5-Fu 600mg／m^2，civ gtt，d2-24，d1-2,2周为1个周期，所有患者至少接受3个周期治疗后评价疗效。结果经3个周期以上治疗后，CR1例，PR14例，NC8例，PD9例。总有效率46．9％，主要毒副反应为神经系统毒性、消化道反应、骨髓抑制、肝肾功能轻度损害。结论草酸铂联合亚叶酸钙、5-氟尿嘧啶治疗晚期胃癌疗效较好，不良反应可耐受。

Observation of clinical effect of FOLFOX4 in treatment of advanced gastric cancer as a second-line regiment

Objective To evaluate the efficiency and toxicity of oxalipaltin （L-OHP）based FOLFOX4 regiment chemotherapy in the treatment of advanced gastric cancer.Methods 32 patients diagnosed advanced gastric cancer, which were relapsed after DF/ECF regiment treatment, were enrolled in the study. The FOLFOX4 chemotherapy regimen was comprised of L-OHP 85 mg/m^2 iv gtt, h0-2, d1;CF 200mg/m^2, iv gtt, 2h,d1-2;5-Fu 400 mg/m^2, iv bolus 2h, d1-2;5-Fu 600 mg/m^2,civ gtt d2-24,d1-2. The regimen was repeated every two weeks. All enrolled patients received at least 3 cycles of treatment before estimating effect. Results After 3 cycles of chemotherapy, complete response was achieved in 1 cases, partial response in 14 cases, stableness in 8 cases and progression in 9 cases, The overall response rate was 46.9%. The side effects included peripheral sensitive neuropathy, digestive tract toxin and hone marrow suppression.Conclusion Oxaliplatin based chemotherapy was effective in controlling advanced gastric cancer patients with acceptable toxicity.